Evaluation of inflammatory and hematological parameters in patients diagnosed with COVID-19.

INTRODUCTION: This study aims to research the effects of hematological and inflammatory parameters on the prognosis of COVID-19 disease and hospitalization duration. METHODOLOGY: One hundred and eighty-six patients with COVID-19 and a control group consisting of 187 healthy individuals were included in the study. Hematological variables and inflammatory parameters of the patients were recorded on the first and the fifth days of hospitalization. RESULTS: White blood cell count, lymphocyte count, and platelet count were statistically lower, and mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) levels were higher in the patient group compared to the control group. It was observed that the neutrophil count and MPV level were lower, and the platelet count and ferritin level were statistically higher on the fifth day of follow-up compared to the admission day. In contrast, there was a significantly positive correlation between the duration of hospitalization and the fifth day D-dimer (r = 0.546, p < 0.001) and ferritin (r = 0.568, p < 0.001); in addition, there was a negative correlation between the duration of hospitalization and admission day lymphocyte count and the fifth-day lymphocyte count. CONCLUSIONS: Increased levels of ferritin and D-dimer, and decreased count of lymphocytes are among the important factors affecting the duration of hospitalization for COVID-19 patients. Furthermore, we think that neutrophil count and MPV levels are low, and platelet count and ferritin levels are high during the disease. Therefore, these parameters can be used as prognostic indicators of the disease.

Which COVID-19 Patients Die in Intensive Care Unit (ICU) in Turkey

A comparison of deceased and surviving patients showed that being female, older than 62, and a smoker and having diabetes mellitus, hypertension, and/or coronary artery disease significantly increased mortality. Information about the patients' age, gender, comorbidities, duration of hospitalization, COVID-19-related lung tomography findings, hemogram parameters (white blood cell (WBC), neutrophil, lymphocyte, and platelet counts, haemoglobin level, neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR), biochemical parameters, and ventilatory support [mechanical ventilation, non-invasive mechanical ventilation (NIMV), high-flow oxygen (HFNO)] were retrospectively accessed in the hospital records. Since the first COVID-19 case was admitted on 15 March, 2020, a total of 618 patients have been diagnosed with COVID-19 in our hospital. The comparison of the deceased and surviving patients also displayed that smoking (p=0.004), diabetes mellitus (p=0.007), hypertension (p=0.042), and coronary artery disease (p=0.049) statistically increased mortality. In our study, the comparison of the laboratory parameters of the deceased and surviving patients showed that the platelet (p=0.006), white blood cell (p=0.048), and neutrophil counts (p=0.033), and NLR (p=0.010) and PLR (p=0.033) were significantly higher in the deceased group compared to the surviving group.

COVID-19 Yoğun Bakım Ünitelerinde Hava Yolu Yönetimi

With the increase in the number of cases, densities were experienced first in the inpatient services and then in the intensive care units, depending on the severity of the disease. The Covid-19 pandemic causes ARDS and multiorgan failure, requiring mechanical ventilators and 3rd step intensive care follow-up in patients. [...]although there is no known specific treatment for the disease, the supportive treatment provided in intensive care units is effective on the morbidity and mortality in the course of the disease. In this article, we aim to explain respiratory support and airway management given to patients with acute respiratory distress and new type of coronavirus infection who need respiratory support. Saǧlık Bakanlıǧı COVÍD-19 tedavi protokolü'ne göre hastanın takibinde aşaǧıdaki bulguların saptanması halinde hasta yoǧun bakıma alınması önerilir8. * Dispne ve solunum distresi olan * Solunum sayısı > 30/dk * PaO2/FiO2 < 300 olan * Oksijen ihtiyacı izlemde artış gösteren * 5 L/dk oksijen tedavisine raǧmen SpO2 < % 90 veya PaO2 < 70 mmHg olan * Hipotansiyon (sistolik kan basıncı < 90 mmHg ve olaǧan SKB dan 40 mmHg dan fazla düşüş ve ortalama arter basıncı < 65 mmHg, taşikardi > 100/ dk * Akut böbrek hasarı, akut karaciǧer fonksiyon testlerinde bozukluk, konfüzyon, akut kanama diyatezi gibi akut organ disfonksiyonu gelişimi ve immünsüpresyonu olan hastalar * Troponin yüksekliǧi ve aritmi * Laktat > 2 mmol Kapiller geri dönüş bozukluǧu ve cutis marmaratus gibi cilt bozukluklarının varlıǧı Bu kriterlere sahip hastaların deǧerlendirilmesi için yoǧun bakım sorumlu hekimlerinden konsultasyon istenmesi önerilir.

Airway Management In COVID-19 Intensive Care Units

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was detected for the first time in Wuhan, China, and cases were detected all over the world and in our country shortly after. With the increase in the number of cases, densities were experienced first in the inpatient services and then in the intensive care units, depending on the severity of the disease. Although it varies from country to country and even regionally, 20-26% of people with COVID-19 infection apply to hospitals with respiratory distress complaints, and 5-10% of these patients are reported to need intensive care. The Covid-19 pandemic causes ARDS and multiorgan failure, requiring mechanical ventilators and 3rd step intensive care follow-up in patients. Therefore, although there is no known specific treatment for the disease, the supportive treatment provided in intensive care units is effective on the morbidity and mortality in the course of the disease. In this article, we aim to explain respiratory support and airway management given to patients with acute respiratory distress and new type of coronavirus infection who need respiratory support. (English) [ FROM AUTHOR] Çin'in Wuhan şehrinde ilk olarak tespit edilen Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) tespit edildikten kısa süre sonra tüm dünyada ve ülkemizde de vakalar tespit edilmiştir. Vaka sayılarının artmasıyla hastalığın şiddetine göre önce yataklı servislerde daha sonra da yoğun bakım ünitelerinde yoğunluklar yaşanmıştır. Covıd-19 enfeksiyonu olan kişilerin ülkeden ülkeye hatta bölgesel olarak farklılık göstermekle birlikte %20-26'lık bir kısmı hastanelere solunum sıkıntısı şikayetleri ile başvurmakta bu hastalarında %5-10'luk kısmının yoğun bakım ihtiyacı olduğu bildirilmektedir. Covid-19 pandemisi ARDS ve multiorgan yetmezliklerine neden olarak hastalarda mekanik ventilatör ihtiyacı ve 3. basamak yoğun bakım takibi gerektirmektedir. Bu nedenle hastalığın bilinen spesifik tedavisi olmamasına rağmen yoğun bakım ünitelerinde sağlanan destek tedavisi ile hastalığın seyrindeki morbibite ve mortalite üzerine etkili olunmaktadır. Bu yazımızda akut solunum sıkıntısı olan ve solunum desteğine ihtiyaç duyan yeni tip koronavirüs enfeksiyonu hastalarına verilen solunum desteği ve hava yolu yönetimi anlatmayı amaçlıyoruz. (Turkish) [ FROM AUTHOR] Copyright of Dicle Medical Journal / Dicle Tip Dergisi is the property of Dicle Tip Dergisi/ Dicle Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)